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Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia

✍ Scribed by See, Hui (author);Yap, Yoke (author);Yip, Wai (author);Seow, Heng (author)

Book ID: 119903516
Publisher: BioMed Central
Year: 2008
Tongue: English
Weight: 349 KB
Volume: 6
Category: Article
ISSN: 1477-7819
DOI: 10.1186/1477-7819-6-18

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A specific variant of Epstein-Barr virus (EBV) with a 30-bp deletion in the C-terminal region of the LMP1 gene has been found in some EBV-associated malignancies. To better understand the tumorigenic role of this LMP1 variant, we used PCR and sequencing to examine the LMP1 gene in 38 EBVassociated c