## Abstract Two human lymphoblastoid cell lines were established by the transformation of human cordβblood lymphocytes with transforming EpsteinβBarr virus (EBV). One cell line (HLBβR1) was established with EBV obtained after the superinfection of Raji cells with HRβ1 EBV and the other (HLBβB1) was
Epstein-Barr virus (EBV)-associated miRNAs are important for the maintenance of EBV transformed B cells
β Scribed by Sarah Linnstaedt, Eva Gottwein, Micah Luftig, Bryan Cullen
- Book ID
- 120697315
- Publisher
- BioMed Central
- Year
- 2010
- Tongue
- English
- Weight
- 178 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1750-9378
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EBV infects B lymphocytes in vivo and establishes a life-long persistent infection in the host. The latent infection is controlled by EBV-specific MHC class 1-restricted CTL. Immunosuppression reduces CTL activity, and this facilitates outgrowth of EBV+ve B cell lymphoproliferative disease (BLPD). B
DNA from malignant cells is present in the serum/plasma of cancer patients and DNA from this source is amenable to analysis by polymerase chain reaction (PCR). In the present study, we evaluated whether Epstein-Barr virus (EBV) DNA is present in the serum of patients with EBV-associated Hodgkin's di