The Epstein-Barr virus (EBV) has been studied for over 25 years as a probable cause of certain human cancers, including nasopharyngeal carcinoma (NPC). This is a low-incidence head and neck cancer in Western countries (including the USA), but is the third-leading cancer in males in Southeast Asia. E
Epstein-Barr virus DNA and epithelial markers in nasopharyngeal carcinoma
โ Scribed by Reinhard E. Friedrich; Sylva Bartel-Friedrich; Hartmut Lobeck; Gerald Niedobitek; Hartmut Arps
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 285 KB
- Volume
- 192
- Category
- Article
- ISSN
- 0300-8584
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Immunologic studies of Epstein-Barr virus (EBV) have implicated EBV in undifferentiated and partially differentiated, non-keratinizing nasopharyngeal carcinoma (NPC). Patients with the well-differentiated, keratinizing form of NPC have EBV serologic patterns similar to those of control populations.
Three stages of maturation can be seen in keratinizing nasopharyngeal carcinomas. These stages are similar morphologically to basal cells, intermediate and superficial squamous cells seen in normal squamous epithelium. Taking advantage of such a diverse tumour cell population, 10 keratinizing nasoph