✦ LIBER ✦

Epstein-Barr virus-associated hemophagocytic syndrome and fatal infectious mononucleosis

✍ Scribed by Okano, Motohiko; Gross, Thomas G.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 450 KB
Volume: 53
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199610)53:2<111::aid-ajh8>3.0.co;2-2

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✦ Synopsis

Virus-associated hemophagocytic syndrome (VAHS) has been thought to be a distinct clinical entity, characterized by intermittent fever, enlarged liver and spleen, and the appearance of hemophagocytosis. Hemopoietic cells are actively ingested by monocytes/macrophages in various organs, including lymph nodes, bone marrow, liver, and spleen. Epstein-Barr virus (EBV) is now thought to be one of the major causes for the development of this unique syndrome. Additionally, VAHS is often associated with fatal infectious mononucleosis (IM). The relationship between EBV-associated VAHS and fatal IM is discussed in this concise review.

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