✦ LIBER ✦

Fatal virus-associated hemophagocytic syndrome associated with coexistent chronic active hepatitis B and acute hepatitis C virus infection

✍ Scribed by Faurschou, Mikkel; Nielsen, Ove Juul; Hansen, Per Boye; Juhl, Birgitte Ravn; Hasselbalch, Hans

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 108 KB
Volume: 61
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199906)61:2<135::aid-ajh11>3.0.co;2-e

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✦ Synopsis

A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia. Liver parameters and serum ferritin were markedly elevated. Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS). There was serological evidence of chronic active hepatitis B and acute hepatitis C virus infection. The patient died despite aggressive immunosuppressive and supportive treatment. Autopsy revealed signs of acute viral hepatitis with cholestasis. Histiocytes engaged in hemophagocytosis were observed in bone marrow and spleen. The condition was interpreted as VAHS associated with chronic active hepatitis B and acute hepatitis C virus infection. To our knowledge this is the first report of a hemophagocytic syndrome in that setting. Am.

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