Epstein-Barr virus-associated antibodies in IgG and IgA of nasopharyngeal carcinoma patients
β Scribed by Czau-siung Yang; Hsi-ming Yang; Yea-sing Yeh; Tsong-chou Lynn
- Book ID
- 119079907
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 527 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0147-9571
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The feasibility of using elevated Epstein-Barr virus (EBV) specific-IgG antiviral capsid antigen (VCA) and IgA anti-VCA antibody levels as an aid in diagnosis of nasopharyngeal carcinoma (NPC) was analyzed by determination of serum antibody titers to EBV in 54 NPC patients, 114 healthy blood donors,
## Abstract In order to better understand the relationship between IgA and IgG antibodies to EpsteinβBarr virus (EBV) in nasopharyngeal carcinoma (NPC), we analyzed 230 NPC sera but also a series of sera from patients with other carcinomas selected for their high EBV/IgG antibody titres. We were su
661 bp coding for the carboxyl end of the large sub-unit of EBV ribonucleotide reductase was cloned into the pMal plasmid vector. Purified recombinant protein was tested in IgG and IgA ELISAs. For the IgG assay, 81 out of 100 NPC patients tested positive, whereas for the IgA assay, 60 tested positiv
## Abstract Stimulated by a report on elevated IgA levels in nasopharyngeal carcinoma (NPC), we tested a total of 372 sera from patients with NPC, other carcinomas of head and neck or elsewhere, Burkitt's lymphoma (BL), infectious mononucleosis (IM) or healthy controls. The sera were titrated in in