Microwave-Promoted Epoxidation of α,β-Unsaturated Ketones in Aqueous Sodium Perborate -[as a safe, mild and convenient synthetic approach to α,β-epoxyketones].
Epoxidation of α,β-unsaturated ketones with sodium perborate
✍ Scribed by Thomas S. Straub
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 98 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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a,/.3-Unsaturatedketones reacted with tetra-n-butylammonium peroxydisu~ate in the presence of hydrogen peroxide and base in acetonitrile at 25 'C to give the corresponding epoxides in excellent yields. @ 1997 Elsevier Science Ltd. Epoxidation of electron deficient olefins such as tx,&unsaturated ket
The corresponding epoxides were isolated in excellent yields via oxygen transfer by dimethyldioxirane ( as acetone solution) . ## a&Unsaturated* ketones and esters are difficult to epoxidixe by peracid or metal-catalyzed methods. The use of