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Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

✍ Scribed by Prof. Dr. Gerhard Höfle; Dr. Norbert Bedorf; Ing. Heinrich Steinmetz; Prof. Dr. Dietmar Schomburg; Dr. Klaus Gerth; Prof. Dr. Hans Reichenbach


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
394 KB
Volume
35
Category
Article
ISSN
0044-8249

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Apicularen A and B, Cytotoxic 10-Membere
✍ Rolf Jansen; Brigitte Kunze; Hans Reichenbach; Gerhard Höfle 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 303 KB 👁 2 views

A novel highly cytotoxic metabolite, apicularen A (1), was isolated in a screening of the myxobacterial genus Chondromyces. The structure of 1 is characterized by a salicylic acid residue as part of a 10-membered lactone, which bears an acylenamine side chain. Compound 1 is an inhibitor of the proli