Epithelial MHC class II sub-region expression in autoimmunity
โ Scribed by Ian Todd; Ricardo Pujol-Borrell; Gian Franco Bottazzo; Marc Feldmann
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 119 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0167-5699
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๐ SIMILAR VOLUMES
It has been proposed that aberrant expression of class II major histocompatibility complex (MHC) molecules by target cells may be an initiating factor in some forms of organ specific autoimmunity. This hypothesis was tested in relation to the autoimmune form of Addison's disease by studying autopsy
The mechanism by which particular MHC class II alleles mediate susceptibility to a given autoimmune disease is unknown. During the past year, reports have indicated that the effects of MHC class II alleles which protect against type I diabetes in the nonobese diabetic mouse strain may, in some cases
## Abstract We first classified 12 malignant glioma cell lines into three different groups (types 1โ3) with respect to major histocompatibility complex (MHC) class II expression and analyzed each group based on the different expression status of the class II transactivator (CIITA) gene. Glioma type