Epithelial membrane antigen and S-100 protein-labeled cells in primary and metastatic laryngeal carcinomas

✍ Scribed by Dr. Tadashi Nakashima; Gen Yano; Drs. Itsuroh Hayashi; Yasaburoh Katsuta

• Book ID: 102848093
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 582 KB
• Volume: 14
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.2880140604

✦ Synopsis

Abstract

Immunohistochemical studies were done on the expression of S‐100 protein‐labeled cells in human laryngeal carcinoma of epithelial membrane antigen (EMA) and on the population density. EMA was detected in 65 of 76 (86%) squamous cell carcinomas and was usually more extensively positive in well and moderately differentiated carcinomas. Thus, EMA can serve as a marker of malignancy in laryngeal carcinomas. The population density of S‐100 protein‐labeled cells was high in well‐differentiated tissues. In the metastatic tumors, the number of S‐100 protein‐labeled cells decreased as compared to findings in the primary tumors. As a statistically significant difference in survival curve was noted between groups with low and intermediate density of S‐100 protein‐labeled cells, the infiltration of S‐100 protein‐labeled cells seems to be associated with a better prognosis. © 1992 John Wiley & Sons, Inc.