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Epileptic focus induced by intrahippocampal cholera toxin in rat: time course and properties in vivo and in vitro

✍ Scribed by S.F. Williams; S.B. Colling; M.A. Whittington; J.G.R. Jefferys

Book ID
103932322
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
929 KB
Volume
16
Category
Article
ISSN
0920-1211

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## Abstract Cholera toxin irreversibly activates a 43‐kDa guanosine triphosphate (GTP)‐binding protein by adenosine diphosphate ribosylation, resulting in activation of adenylate cyclase and increased intracellular levels of cyclic adenosine monophosphate (cAMP). Because increases in intracellular