Epigenetics: Linking Genotype and Phenotype in Development and Evolution

✍ Scribed by Benedikt Hallgrimsson (editor); Brian K. Hall (editor)

Publisher: University of California Press
Year: 2011
Tongue: English
Leaves: 468
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.

✦ Table of Contents

Contents
Contributors
1. Introduction
Part One. Historical and Philosophical Foundations
2. A Brief History of the Term and Concept Epigenetics
3. Heuristic Reductionism and the Relative significance of Epigenetic Inheritance in evolution
Part Two. Approaches to Epigenetics
4. The Epigenetics of Genomic Imprinting: Core Epigenetic Processes are conserved in Mammals, Insects, and Plants
5. Methylation Mapping in Humans
6. Asexuality and Epigenetic Variation
7. Epigenesis, Preformation, and the Humpty Dumpty Problem
8. A Principle of Developmental Inertia
Part Three. Epigenetics of Vertebrate Organ Development
9. The Role of Epigenetics in Nervous System Development
10. Morphogenesis of Pigment Patterns: Experimental and Modeling Approaches
11. Epigenetic Interactions of the Cardiac Neural Crest
12. Epigenetics in Bone and cartilage Development
13. Muscle–Bone Interactions and the Development of skeletal Phenotype: Jaw muscles and the skull
14. Evolution of the Apical Ectoderm in the Developing Vertebrate Limb
15. Role of Skeletal Muscle in the Epigenetic Shaping of Organs, Tissues, and Cell Fate Choices
Part Four. Epigenetics in Evolution and Disease
16. Epigenetic Integration, Complexity, and Evolvability of the Head: Rethinking the Functional Matrix Hypothesis
17. Epigenetic Interactions: The Developmental Route to Functional Integration
18. Epigenetic Contributions to Adaptive Radiation: Insights from Threespine Stickleback
19. Learning, Developmental Plasticity, and the Rate of Morphological Evolution
20. Epigenetics: Adaptation or Contingency?
21. The Epigenetics of Dysmorphology. Craniosynostosis as an Example
22. Epigenetics of Human Disease
23. Epigenetics: The Context of Development
Index

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