Epigenetics in Acute Myeloid Leukemia
β Scribed by Christoph Plass; Christopher Oakes; William Blum; Guido Marcucci
- Book ID
- 114474174
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 323 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0093-7754
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Survivin, an inhibitor of apoptosis (IAP) protein plays a dual role in regulation of mitosis and inhibition of apoptosis. Survivin is expressed in embryonic and fetal organs as well as in most human cancers, but not in normal differentiated adult tissues. In this study we investigated the molecular
We have demonstrated that constitutive signal transducer and activator of transcription (STAT) 3 activity, observed in approximately 50% of acute myeloid leukemia (AML) cases, is associated with adverse treatment outcome. Constitutive STAT3 activation may result from the expression of oncogenic prot