## Abstract Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genomeβwide methylation analysis of five sporadic breast carcinomas we identified a hypermethylate
β¦ LIBER β¦
Epigenetic silencing of the tumor suppressor klotho in human breast cancer
β Scribed by Tami Rubinek, Michal Shulman, Shira Israeli, Shikha Bose, Ayelet Avraham, Adi Zundelevich, Ella Evron, Einav Nili Gal-Yam, Bella Kaufman, Ido Wolf
- Book ID
- 113062325
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 598 KB
- Volume
- 133
- Category
- Article
- ISSN
- 0167-6806
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Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers. Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise role in normal mammary epithelium remains to be elucidated. Although expression of maspin mRNA is low or absent in most