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Epigenetic silencing of the LDOC1 tumor suppressor gene in ovarian cancer cells

✍ Scribed by Buchholtz, Marie-Luise; Brüning, Ansgar; Mylonas, Ioannis; Jückstock, Julia

Book ID
121546560
Publisher
Springer
Year
2014
Tongue
English
Weight
443 KB
Volume
290
Category
Article
ISSN
0003-9128

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## Abstract Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genome‐wide methylation analysis of five sporadic breast carcinomas we identified a hypermethylate