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Epigenetic silencing of HSulf-1 in ovarian cancer:implications in chemoresistance

✍ Scribed by Chien, J; Pan, Y; Qian, X; Narita, K; Aletti, G; Scheerer, M; Roberts, L R; Molina, J; Shridhar, V; Staub, J

Book ID: 110072297
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 528 KB
Volume: 26
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1210300

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## Abstract The __HSulf‐1__ gene is an important factor that modulates the sulfation status of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix, resulting in disturbance of HSPG‐related signal transduction pathways. Recently, __HSulf‐1__ has been reported to be down‐regulated in se