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Epigenetic regulation ofCD34andHIF1Aexpression during the differentiation of human mast cells

✍ Scribed by Aurelia Walczak-Drzewiecka, Anna Salkowska, Marcin Ratajewski…

Book ID
120766477
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
305 KB
Volume
65
Category
Article
ISSN
0093-7711

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The human telomerase reverse transcriptase (TERT) gene is transcriptionally inactivated in most differentiated cells but is reactivated in the majority of cancer cells. To elucidate how TERT is inactivated during differentiation, we applied all-trans retinoic acid (ATRA) to induce the differentiatio