Epigenetic Regulation of Vascular Endothelial Biology/Pathobiology and Response to Fluid Shear Stress
β Scribed by Jing Zhou; Seh Hong Lim; Jeng-Jiann Chiu
- Book ID
- 107620777
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 763 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1865-5025
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## Abstract An in vitro model of vascular damage was used to investigate the ability of seeded endothelial cells to resist shear stresses generated in a perfusion circuit. At perfusion rates of 100 ml/min the maximum shear stress reached 16.5 dyn/cm2. At this level the rate of cell detachment from
## Abstract An important physiological function of vascular endothelial cells is to detect and respond to physical stimuli. While many efforts have been made to derive endothelial cells from human embryonic stem cells (hESCs), the ability of these derivatives to respond to mechanical forces has yet
## Abstract Most acute coronary events occur in the upstream region of stenotic atherosclerotic plaques that experience laminar shear stress (LSS) elevated above normal physiological levels. Many studies have described the atheroprotective effect on endothelial behavior of normal physiological LSS
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