๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Effect of pulsatile shear stress on endothelial attachment to native vascular surfaces

โœ Scribed by Mr M. M. Thompson; J. S. Budd; S. L. Eady; R. F. L. James; P. R. F. Bell

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
718 KB
Volume
81
Category
Article
ISSN
0007-1323

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โœฆ Synopsis

Abstract

An in vitro model of vascular damage was used to investigate the ability of seeded endothelial cells to resist shear stresses generated in a perfusion circuit. At perfusion rates of 100 ml/min the maximum shear stress reached 16.5 dyn/cm2. At this level the rate of cell detachment from the damaged vascular surface was 88 per cent per h for the first 20 min of flow but gradually decreased to 5 per cent per h after 90 min. These findings suggest that endothelial cells may be retained on damaged vascular surfaces in conditions that approximate to arterial flow.

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