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Epigenetic regulation of tumor suppressors in t(8:21)-containing AML

✍ Scribed by Genyan Yang; Waleed Khalaf; Louis Locht; JoopH. Jansen; BertA. Reijden; Carsten Müller-Tidow; H.Ruud Delwel; Hubert Serve; D.Wade Clapp; ScottW. Hiebert

Book ID
105988399
Publisher
Springer
Year
2004
Tongue
English
Weight
106 KB
Volume
83
Category
Article
ISSN
0939-5555

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✍ Frank G. Rücker; Lars Bullinger; Alexander Gribov; Martin Sill; Richard F. Schle 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 540 KB

## Abstract In acute myeloid leukemia (AML), nonrandom clonal chromosome aberrations are detectable in ∼55% of adult cases. Translocation t(8;21)(q22;q22) resulting in the 5′__RUNX1__/3′__RUNX1T1__ fusion gene occurs in ∼8% of AML cases. Also, ins(8;21) and ins(21;8) have been described that show a