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Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes

โœ Scribed by Meng, F; Wehbe-Janek, H; Henson, R; Smith, H; Patel, T

Book ID
110072638
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
196 KB
Volume
27
Category
Article
ISSN
0950-9232

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โœ Chiara Braconi; Nianyuan Huang; Tushar Patel ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 627 KB

Although the inflammation-associated cytokine interleukin-6 (IL-6) has been implicated in cholangiocarcinoma growth, the relationship between IL-6 and oncogenic changes is unknown. IL-6 can increase expression of DNA methyltransferase-1 (DNMT-1) and epigenetically regulate the expression of several