Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes
β Scribed by Fanyin Meng; Yoko Yamagiwa; Yoshiyuki Ueno; Tushar Patel
- Book ID
- 116650954
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 515 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0168-8278
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Although the inflammation-associated cytokine interleukin-6 (IL-6) has been implicated in cholangiocarcinoma growth, the relationship between IL-6 and oncogenic changes is unknown. IL-6 can increase expression of DNA methyltransferase-1 (DNMT-1) and epigenetically regulate the expression of several