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Epigenetic inactivation of BRCA1 through promoter hypermethylation in ovarian cancer progression

✍ Scribed by Yan-Qiu Wang; Qin Yan; Jia-Rong Zhang; Shuang-Di Li; Yi-Xia Yang; Xiao-Ping Wan

Book ID
119845241
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
197 KB
Volume
39
Category
Article
ISSN
1341-8076

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## Abstract The retinoblastoma protein‐interacting zinc finger gene, __RIZ1__ (GenBank accession number U17838), is involved in chromatin‐mediated gene expression and is also a target for frameshift mutation in microsatellite‐unstable cancers. Methylation of the __RIZ1__ promoter CpG island has bee