Epigenetic DNA-(cytosine-5-carbon) modifications: 5-aza-2′-deoxycytidine and DNA-demethylation
✍ Scribed by S. K. Patra; S. Bettuzzi
- Book ID
- 110155178
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 203 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0006-2979
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## Abstract The objective was to evaluate the effects of 5‐AZA‐2′‐deoxycytidine (5‐AZA‐CdR) on postnatal development and reproductive capacity. Pregnant mice were administered 1 mg kg−1 5‐AZA‐CdR at gestation day 10. The body weights of F1 control and treated (in uterine‐exposed) pups were recorded
## Abstract Cancer/testis antigens (CTAs) are considered to be suitable targets for the immunotherapy of human malignancies. It has been demonstrated that in a variety of tumors, the expression of certain CTAs is activated __via__ the demethylation of their promoter CpG islands. In our study, we ha