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5-Aza-2′-deoxycytidine Induces Histone Hyperacetylation of Mouse Centromeric Heterochromatin by a Mechanism Independent of DNA Demethylation

✍ Scribed by Shin-ichiro Takebayashi; Mitsuyoshi Nakao; Naoyuki Fujita; Takashi Sado; Minoru Tanaka; Hiroshi Taguchi; Katsuzumi Okumura


Book ID
115588912
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
471 KB
Volume
288
Category
Article
ISSN
0006-291X

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5-Aza-2′-deoxycytidine induces p21WAF ex
✍ Karin Schmelz; Mandy Wagner; Bernd Dörken; Ingo Tamm 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 1005 KB

## Abstract The DNA methylation inhibitor 5‐Aza‐2′‐deoxycytidine (5‐Aza‐CdR) has significant therapeutic value for the treatment of patients with myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). The demethylating effect of 5‐Aza‐CdR has been well char