𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

✍ Scribed by Valerie Greger; Eberhard Passarge; Wolfgang Höpping; Elmar Messmer; Bernhard Horsthemke

Book ID
104705570
Publisher
Springer
Year
1989
Tongue
English
Weight
409 KB
Volume
83
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

✦ Synopsis

Epigenetic models for tumor formation assume that oncogenic transformation results from changes in the activity of otherwise normal genes. Since gene activity can be inhibited by DNA methylation, and inactivation of tumor suppressor genes is a fundamental process in oncogenesis, we investigated the methylation status of the retinoblastoma suppressor gene (RB gene) on chromosome 13, in blood and tumor cells from 21 retinoblastoma patients. Using methylation-sensitive restriction enzymes and a cloned DNA probe for the unmethylated CpG island at the 5' end of RB gene, we obtained evidence of hypermethylation of this gene in a sporadic unilateral retinoblastoma tumor. The closely linked esterase D gene and a CpG-rich island on chromosome 15 were not affected. We suggest that changes in the methylation pattern of the RB gene play a role in the development and spontaneous regression of some retinoblastoma tumors.

📜 SIMILAR VOLUMES

Changes in chromosome positioning may co
Changes in chromosome positioning may contribute to the development of diseases related to X-chromosome aneuploidy
✍ Natalia V Petrova; Irina I. Yakutenko; Andrei V. Alexeevski; Valentin A. Verbovo 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 238 KB

## Abstract The radial positions of the centromeric regions of chromosomes 1 and X were determined in normal male fibroblasts (XY) and in fibroblasts from a patient with a rare case of XXXXY polysomy. The centromeric regions and presumably the whole territories of active X chromosomes were demonstr

The fetishism of modernities: Epochal se
The fetishism of modernities: Epochal self-consciousness in contemporary social and political thought; The era of the individual: A contribution to the history of subjectivity; The rise of the social sciences and the formation of modernity: Conceptual change in context, 1750–1850; Modernism: An anthology of sources and documents
✍ Marlene Shore 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 357 KB

. ## Christopher Lane's The Burdens of Intimacy: Psychoanalysis and Victorian Masculinity interprets examples of Victorian literature as studies in the nature and functioning of desire. Specifically, the book examines the works of Edward George Bulwer-Lytton, Algernon

Interesting Studies and Facts of Drug Ma
Interesting Studies and Facts of Drug Market Conditions**In order to present viewpoints on the significance of prevailing market conditions, Mr. Harry B. French, President of Smith, Kliue & French Company was asked for his opinion, and the substance of the editorial, “The Significance of Present Drug Market Conditions,” submitted to him for comment. A few changes were made in the editorial and these may account for the slight difference in viewpoint on the alcohol situation. The readers will value these interesting contributions by leading authorities.
📂 Article 📅 1920 🏛 Elsevier ⚖ 178 KB