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Changes in chromosome positioning may contribute to the development of diseases related to X-chromosome aneuploidy

โœ Scribed by Natalia V Petrova; Irina I. Yakutenko; Andrei V. Alexeevski; Valentin A. Verbovoy; Sergey V. Razin; Olga V. Iarovaia

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
238 KB
Volume
213
Category
Article
ISSN
0021-9541

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โœฆ Synopsis

Abstract

The radial positions of the centromeric regions of chromosomes 1 and X were determined in normal male fibroblasts (XY) and in fibroblasts from a patient with a rare case of XXXXY polysomy. The centromeric regions and presumably the whole territories of active X chromosomes were demonstrated to occupy similar, although not identical, positions in XY and XXXXY cells. The centromeres of inactive X chromosomes (Barr bodies) were located closer to the nuclear periphery as compared with the centromeres of active X chromosomes. In addition, it was established that the nuclear radial position of geneโ€rich chromosome 1 was changed in XXXXY cells as compared to normal XY cells. The data are discussed in the context of the hypothesis postulating that changes in nuclear positioning of chromosomal territories induced by the presence of extra copies of individual chromosomes may contribute to the development of diseases related to different polysomies. J. Cell. Physiol. 213: 278โ€“283, 2007. ยฉ 2007 Wileyโ€Liss, Inc.

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