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Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

✍ Scribed by Diego Mastroeni; Andrew Grover; Elaine Delvaux; Charisse Whiteside; Paul D. Coleman; Joseph Rogers


Book ID
116781452
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
951 KB
Volume
31
Category
Article
ISSN
0197-4580

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## Abstract We developed a novel quantitative assay to test the hypothesis that defects in DNA cytosine methylation might be responsible for the brain chromatin abnormalities and transcriptional alterations observed in patients with Alzheimer's disease (AD). We found no significant difference in pe