(−)-Epigallocatechin-3-gallate downregulates estrogen receptor alpha function in MCF-7 breast carcinoma cells
✍ Scribed by Fulvia Farabegoli; Cristiana Barbi; Elisabetta Lambertini; Roberta Piva
- Book ID
- 113524468
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 488 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0361-090X
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Estrogens are mitogenic for estrogen receptor (ER)-positive breast cancer cells. Current treatment of ER-positive breast tumors is directed towards interruption of estrogen activity. We report that treatment of ER-positive breast cancer cells with kaempferol resulted in a time- and dose-dependent de
## Scope: The aim of this research was to explore whether the tea-polyphenol (-)-epigallocatechin-3-gallate (egcg) could be used as a potential agent for blocking smoking (nicotine, nic)- or hormone (estradiol, e2)-induced breast cancer cell proliferation through inhibition of a common signaling pa