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Role of the proteasome in the regulation of estrogen receptor α turnover and function in MCF-7 breast carcinoma cells

✍ Scribed by Ioanna Laïos; Fabrice Journé; Denis Nonclercq; Doris Salazar Vidal; Robert-Alain Toillon; Guy Laurent; Guy Leclercq


Book ID
116697587
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
521 KB
Volume
94
Category
Article
ISSN
0960-0760

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This report describes an investigation of the role of 1,25-dihydroxyvitamin D (VD 3 ) in the regulation of estrogen receptor-␣ (ER) in the ER-positive breast cancer cell line, MCF-7. Treatment of cells with 10 nM VD 3 resulted in a 50% decline in the concentration of ER protein at 24 h. Scatchard an