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Epidermal growth factor receptor tyrosine kinase inhibitors induce CCL2 and CCL5 via reduction in IL-1R2 in keratinocytes

✍ Scribed by Mayuko Yamaki; Kazumitsu Sugiura; Yoshinao Muro; Yoshie Shimoyama; Yasushi Tomita

Book ID: 111244704
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 540 KB
Volume: 19
Category: Article
ISSN: 0906-6705
DOI: 10.1111/j.1600-0625.2010.01108.x

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## Abstract ## BACKGROUND: Somatic mutations in the epidermal growth factor receptor (EGFR) kinase domain are associated with sensitivity to EGFR‐tyrosine kinase inhibitors (EGFR‐TKI) in patients with nonsmall cell lung cancer (NSCLC). ## METHODS: The authors tested the possibility that nucleoti