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Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer: Impact of Primary or Secondary Mutations

✍ Scribed by Akira Sakurada; Frances A. Shepherd; Ming-Sound Tsao


Book ID
119935554
Publisher
CIG Media Group, LP.
Year
2006
Tongue
English
Weight
150 KB
Volume
7
Category
Article
ISSN
1525-7304

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## Abstract ## BACKGROUND: Somatic mutations in the epidermal growth factor receptor (EGFR) kinase domain are associated with sensitivity to EGFR‐tyrosine kinase inhibitors (EGFR‐TKI) in patients with nonsmall cell lung cancer (NSCLC). ## METHODS: The authors tested the possibility that nucleoti