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Epidermal Growth Factor Receptor Signaling in Hepatocellular Carcinoma: Inflammatory Activation and a New Intracellular Regulatory Mechanism

✍ Scribed by Berasain, Carmen; Nicou, Alexandra; Garcia-Irigoyen, Oihane; Latasa, M. Ujue; Urtasun, Raquel; Elizalde, Maria; Salis, Fabiana; Perugorría, María J.; Prieto, Jesús; Recio, Juan A.; Corrales, Fernando J.; Avila, Matías A.


Book ID
119985893
Publisher
S. Karger AG
Year
2012
Tongue
English
Weight
871 KB
Volume
30
Category
Article
ISSN
0257-2753

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## Abstract The idea of a receptor reserve in mediating cellular function is well known but direct biochemical evidence has not been easy to obtain. This study stems from our results showing that L15 of epidermal growth factor (EGF) is important in both EGF receptor (EGFR) binding and activation, a