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Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours

✍ Scribed by Marc-Eric Halatsch; Ursula Schmidt; Julianne Behnke-Mursch; Andreas Unterberg; Christian Rainer Wirtz


Book ID
116395024
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
334 KB
Volume
32
Category
Article
ISSN
0305-7372

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## Abstract In __de novo__ glioblastoma multiforme, loss of the tumour suppressor protein PTEN can coincide with the expression of a naturally occurring mutant epidermal growth factor receptor known as Ξ”EGFR. Ξ”EGFR signals constitutively via the phosphatidylinositol 3‐kinase (PI3K)/protein kinase A