Epidermal growth factor, like phorbol esters, induces plasminogen activator in HeLa cells
β Scribed by LEE, LIH-SYNG; BERNARD WEINSTEIN, I.
- Book ID
- 109710432
- Publisher
- Nature Publishing Group
- Year
- 1978
- Tongue
- English
- Weight
- 216 KB
- Volume
- 274
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/274696a0
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In the human glioblastoma cell line, T-MG1, plasminogen activator activity (PA-activity) was demonstrated by using the chromogenic substrate S-2251. Using monoclonal antibodies against human urokinase type PA (u-PA) and human tissue type PA (t-PA), only u-PA activity was found in T-MG1 cell extracts
## Abstract 5β²βNitroβindirubinoxime (5β²βNIO), a derivative of indirubin, exhibits antiβcancer activity in a variety of human cancer cells. However, the underlying molecular mechanisms and molecular target(s) of the chemopreventive activities of 5β²βNIO remain unknown. Here, we report that 5β²βNIO inh