Phorbol-ester-stimulated human lymphoid cell lines produce a plasminogen activator modulator inducing cell-bound urokinase-type plasminogen activator in malignant tumor cell lines

Counteraction of estradiol-induced activ

Counteraction of estradiol-induced activation of tissue-type plasminogen activator in a human breast cancer cell line by an anti-estrogen, LY117018

✍ T. Uchiumi; H. Mizoguchi; Y. Hagino; K. Kohno; M. Kuwano 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 718 KB

L Y I 17018 is a non-steroid anti-estrogen which exhibits about 100 times higher affinity for estrogen receptor than tamoxifen, another anti-estrogen. The cell line ES-I , which was isolated from human breast cancer MCF-7 cells, was highly sensitive to the cytocidal action of estradiol. Growth of ES