Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells
✍ Scribed by Edward B. Leof; Walker Wharton; Judson J. Van Wyk; W.J. Pledger
- Book ID
- 115891515
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 703 KB
- Volume
- 141
- Category
- Article
- ISSN
- 0014-4827
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## Abstract Methylglyoxal bis‐(guanylhydrazone) (mGBG) blocked the stimulation of DNA synthesis in quiescent, density‐inhibited BALB/c‐3T3 cells treated with platelet‐derived growth factor (PDGF) and platelet‐poor plasma (PPP). Competence formation produced by a transient exposure to PDGF was not e
## Abstract The great majority of murine Balb/c‐3T3 fibroblasts in density‐inhibited, quiescent cultures disintegrate and die rapidly when cells are deprived of serum in the medium. Platelet‐derived growth factor (PDGF, 5 ng/ml) used alone and insulin‐like growth factor (IGF‐1, 40 ng/ml) + epiderma