Epidermal enzymes as penetration enhancers in transdermal drug delivery?
β Scribed by Sunita Patil; Parminder Singh; Christiane Szolar-Platzer; Howard Maibach
- Book ID
- 109388399
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 229 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0022-3549
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The aim of this study was to investigate the dermal administration of a highly hydrophilic model drug, diphenhydramine (DPH), in colloidal systems with an aqueous colloidal phase in the presence of a glycolipid (GL) as a penetration modifier. Dermal penetration of DPH, GL, and isopropylpalmitate (IP
## Abstract Oligodimethylsiloxanes (ODMSs) containing a 2βpyrrolidone moiety at one chain end were prepared to develop a siliconeβbased transdermal penetration enhancer. The 1βalkylβ2βpyrrolidonβ3βyl group was introduced as a terminal group of ODMS via the initiator method, i.e., the anionic ringβo