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EpCAM Is Overexpressed in Breast Cancer and Is a Potential Target for Breast Cancer Gene Therapy

✍ Scribed by Osta, W. A.

Book ID
121841145
Publisher
American Association for Cancer Research
Year
2004
Tongue
English
Weight
331 KB
Volume
64
Category
Article
ISSN
0008-5472

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## Abstract The amplification of the q21 band of chromosome 8 (8q21) occurs in a large percentage of breast cancers. WWP1, an HECT domain‐containing ubiquitin E3 ligase located in the 8q21 region, negatively regulates the TGF‐β tumor suppressor pathway. To characterize the role of __WWP1__ in breas