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EO9: relationship between DT-diaphorase levels and response in vitro and in vivo

โœ Scribed by Collard, J; Matthew, AM; Double, JA; Bibby, MC


Book ID
109837118
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
940 KB
Volume
71
Category
Article
ISSN
0007-0920

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Relevance of DT-diaphorase activity to m
โœ Masahiko Nishiyama; Shuji Saeki; Kenjiro Aogi; Naoki Hirabayashi; Tetsuya Toge ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 510 KB

Using 4 human cancer cell lines, 4 tumors xenografted into nude mice, and I I fresh tumor specimens removed at surgery, we investigated the relevance of NAD(P)H:quinone oxidoreductase (DT-diaphorase, DTD) activity (nmoles/min/mg protein) to mitomycin C (MMC)-induced cytotoxicity. In culture cell lin