Enzymic reduction of an epoxide to an alcohol
โ Scribed by Steckbeck, Sharon R.; Nelson, James A.; Spencer, Thomas A.
- Book ID
- 126430391
- Publisher
- American Chemical Society
- Year
- 1982
- Tongue
- English
- Weight
- 420 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0002-7863
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Asymmetric Synthesis of CDP840 by Jacobsen Epoxidation. An Unusual Syn-Selective Reduction of an Epoxide. -The catalytic asymmetric synthesis of the PDE (IV) inhibitor, CDP840 (R)-(VI), useful as antiasthmatic agent, is presented. The absolute stereochemistry is controlled by a Jacobsen epoxidation