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Enzyme-Promoted Desymmetrisation of Prochiral Bis(cyanomethyl) Sulfoxide

✍ Scribed by Piotr Kiełbasiński; Michał Rachwalski; Marian Mikołajczyk; Małgorzata Szyrej; Michał W. Wieczorek; Roel Wijtmans; Floris P. J. T. Rutjes


Book ID
101423593
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
88 KB
Volume
349
Category
Article
ISSN
1615-4150

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Desymmetrisation of prochiral ketones by
✍ Andrew J Carnell; Jim Barkley; Amarjit Singh 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 195 KB

Desymmetrisation of 4-cyano-4-phenylcyclohexanone I has been achieved by enzyme-catalysed enantioselective alcoholysis with n-butanol of the derived rscemic enol acetate 2 in tetrahydrofuran. The absolute configuration of the enol acetate (-)-(S)-2 (100% e.e.) obtained was determined by X-my analysi