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Desymmetrisation of prochiral ketones by catalytic enantioselective hydrolysis of their enol esters using enzymes

✍ Scribed by Andrew J Carnell; Jim Barkley; Amarjit Singh

Book ID: 104258117
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 195 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01817-0

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✦ Synopsis

Desymmetrisation of 4-cyano-4-phenylcyclohexanone I has been achieved by enzyme-catalysed enantioselective alcoholysis with n-butanol of the derived rscemic enol acetate 2 in tetrahydrofuran. The absolute configuration of the enol acetate (-)-(S)-2 (100% e.e.) obtained was determined by X-my analysis of the camphanyl derivative 7.

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