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Enzyme-catalyzed synthesis of (S)-cyanohydrins and subsequent hydrolysis to (S)-α-hydroxy-carboxylic acids

✍ Scribed by Franz Effenberger; Brigitte Hörsch; Siegfried Förster; Thomas Ziegler


Book ID
104222045
Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
204 KB
Volume
31
Category
Article
ISSN
0040-4039

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✍ Paul V. Fish; Malcolm Mackenny; Gerwyn Bish; Timothy Buxton; Russell Cave; David 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 163 KB

The (R)-and (S)-N-Boc-morpholine-2-carboxylic acids 9 and 10 were prepared using an enantioselective synthesis employing a highly selective enzyme-catalyzed kinetic resolution of racemic n-butyl 4-benzylmorpholine-2-carboxylate (11) as the key step. Acids 9 and 10 were then converted efficiently and