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Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

โœ Scribed by Kenneth E. Thummel; Kent L. Kunze; Danny D. Shen

Book ID
114176448
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
269 KB
Volume
27
Category
Article
ISSN
0169-409X

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It was reported that the mean value of the extent of absolute oral bioavailability (F) of oltipraz at a dose of 20 mg/kg was 41.2% and only 2.68% of the oral dose was unabsorbed from the gastrointestinal tract in rats. Hence, the low F in rats could be due to considerable first-pass (gastric, intest