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Enzyme 15-lipoxygenase 1 promotes hypoxia-inducible factor 1 α turnover and reduces vascular endothelial growth factor expression: implications for angiogenesis

✍ Scribed by Zhong, Hua; Wang, Ruoxiang; Kelavkar, Uddhav; Wang, Christopher Y.; Simons, Jonathan


Book ID
121710089
Publisher
Wiley (John Wiley & Sons)
Year
2014
Tongue
English
Weight
384 KB
Volume
3
Category
Article
ISSN
2045-7634

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## Abstract In oxygenated cells, hypoxia‐inducible factor‐1 (HIF‐1) α subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippel–Lindau tumor suppressor E3 ligase complex using 2‐oxoglutarate as a substrate. We examined the effect of 2‐oxoglutarate on the production