Enzymatic resolution of racemic ibuprofe
โ
Masahiro Goto; Sadafumi Noda; Noriho Kamiya; Fumiyuki Nakashio
๐
Article
๐
1996
๐
Springer Netherlands
๐
English
โ 286 KB
Surfactant-coated lipases have been utilized as a biocatalyst for the resolution of racemic ibuprofen. S-(+)-ibuprofen was selectively transferred to the ester form by Mucor javanicus or Candida rugosa lipase. The enzymatic activity of lipases in organic media was remarkably enhanced by coating with