The enantioselective synthesis of optically active (R)~cyanohydrins generated from several aromatic, heteroaromalic and aliphatic aldehydes and methyl ketones was carried out using almond. peach or Ioquat meal as (R)-oxynitrilase sources in diisopropyl ether under micro-aqueous conditions. The micro
Enzymatic synthesis of (R)-cyanohydrins by a novel (R)-oxynitrilase fromVicia sativaL.
โ Scribed by Shi-Qing Han; Ping-Kai Ouyang; Ping Wei; Yi Hu
- Book ID
- 106363689
- Publisher
- Springer Netherlands
- Year
- 2006
- Tongue
- English
- Weight
- 179 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0141-5492
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A novel spiropiperidine system i.e an aza structural analog of histrionicotoxin has been constructed from 2-cyano-6-phenyloxazolopiperidine synthon 3. The suitable quaternary carbon was created by alkylation at the position c~ ta the nitrile fallowed by transformation of the nitrile group into a pri