PIDA [phenyliodine(III) diacetate] in AcOH or AcOH-HFIP (hexafluoroisopropanol) efficiently promotes the formation of 2,5-disubstituted oxazoles via the oxidative cycloisomerization of propargylamide derivatives.
Enzymatic synthesis of propargylamides
โ Scribed by Francisca Rebolledo; Rosario Brieva; Vicente Gotor
- Book ID
- 104244865
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 127 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
## Abstract **Summary:** An amphiphilic poly(__N__โpropargylamide) with galactose and lauryloyl groups was synthesized by copolymerization of the corresponding __N__โpropargylamide monomers using a Rh catalyst. The obtained copolymer formed a oneโhanded helical conformation and molecular aggregates
In the presence of Pd 2 (dba) 3 -Cy 3 P catalyst, IPrรHCl salt [IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2ylidene], and Cs 2 CO 3 , N-propargylamides react with allyl carbonates to give 2,5-disubstituted oxazoles having homoallyl groups through the tandem cycloisomerization-allylation.