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Amphiphilic Poly(N-propargylamide) with Galactose and Lauryloyl Groups: Synthesis and Properties

✍ Scribed by Masakazu Suenaga; Yoshiro Kaneko; Jun-ichi Kadokawa; Takehiro Nishikawa; Hidezo Mori; Masayoshi Tabata

Book ID
102471850
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
343 KB
Volume
6
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Summary: An amphiphilic poly(N‐propargylamide) with galactose and lauryloyl groups was synthesized by copolymerization of the corresponding N‐propargylamide monomers using a Rh catalyst. The obtained copolymer formed a one‐handed helical conformation and molecular aggregates in water. The observations by fluorescence microscopy in a cell culture experiment in the presence of dye‐labeled copolymer indicated that the copolymer was incorporated into the cells.

Localization of rhodamine B‐labeled copolymer 8 in human aortic endothelial cells (fluorescence image).

magnified imageLocalization of rhodamine B‐labeled copolymer 8 in human aortic endothelial cells (fluorescence image).

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